Development of Streptomyces sp. FR-008 as an emerging chassis
نویسندگان
چکیده
منابع مشابه
Development of Streptomyces sp. FR-008 as an emerging chassis☆
Microbial-derived natural products are important in both the pharmaceutical industry and academic research. As the metabolic potential of original producer especially Streptomyces is often limited by slow growth rate, complicated cultivation profile, and unfeasible genetic manipulation, so exploring a Streptomyces as a super industrial chassis is valuable and urgent. Streptomyces sp. FR-008 is ...
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In the arsenic resistance gene cluster from the large linear plasmid pHZ227, two novel genes, arsO (for a putative flavin-binding monooxygenase) and arsT (for a putative thioredoxin reductase), were coactivated and cotranscribed with arsR1-arsB and arsC, respectively. Deletion of the ars gene cluster on pHZ227 in Streptomyces sp. strain FR-008 resulted in sensitivity to arsenic, and heterologou...
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15 صفحه اولTailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.
Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.
متن کاملDraft Genome Sequence of Streptomyces sp. TP-A0890, a Producer of FR-900452 and A-74863a
Here, we report the draft genome sequence of Streptomyces sp. TP-A0890, a producer of FR-900452 and A-74863a. The genome was found to contain at least eight polyketide synthase and nonribosomal peptide synthetase gene clusters. A prediction of gene functions based on the sequence similarity allowed us to assign the biosynthetic gene clusters for FR-900452 and A-74863a.
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ژورنال
عنوان ژورنال: Synthetic and Systems Biotechnology
سال: 2016
ISSN: 2405-805X
DOI: 10.1016/j.synbio.2016.07.002